败血症是一种威胁生命的患有器官功能障碍的疾病,是全球死亡和重症疾病的主要原因。急诊科分类过程中败血症的准确检测将允许尽早开始实验室分析,抗生素给药和其他败血症治疗方案。这项研究的目的是确定是否可以将EHR数据与最新的机器学习算法(Kate Sepsis)和临床自然语言处理一起提取和合成,以产生准确的脓毒症模型,并将Kate Sepsis与现有的败血症筛查方案进行比较爵士和QSOFA。使用来自16家参与医院的分类数据的患者遇到的患者遭遇开发了机器学习模型(Kate Sepsis)。凯特败血症,SIRS,标准筛查(具有感染源的SIRS)和QSOFA在三个设置中进行了测试。队列A是对单个站点1的医疗记录的回顾性分析。同类B是对位点1的前瞻性分析1.同伴C是对站点1的回顾性分析,并有15个地点。在所有队列中,凯特败血症的AUC为0.94-0.963,TPR为73-74.87%和3.76-7.17%FPR。标准筛选显示AUC为0.682-0.726,TPR为39.39-51.19%和2.9-6.02%FPR。 QSOFA协议的AUC为0.544-0.56,TPR为10.52-13.18%和1.22-1.68%FPR。对于严重的败血症,在所有队列中,凯特败血症的AUC为0.935-0.972,TPR为70-82.26%和4.64-8.62%FPR。对于败血性休克,在所有队列中,凯特败血症的AUC为0.96-0.981,TPR为85.71-89.66%和4.85-8.8%FPR。 SIRS,标准筛选和QSOFA表现出严重败血症和败血性休克检测的低AUC和TPR。凯特败血症在分类中提供的败血症检测性能比常用的筛查方案更好。
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Objective: We aim to develop an open-source natural language processing (NLP) package, SODA (i.e., SOcial DeterminAnts), with pre-trained transformer models to extract social determinants of health (SDoH) for cancer patients, examine the generalizability of SODA to a new disease domain (i.e., opioid use), and evaluate the extraction rate of SDoH using cancer populations. Methods: We identified SDoH categories and attributes and developed an SDoH corpus using clinical notes from a general cancer cohort. We compared four transformer-based NLP models to extract SDoH, examined the generalizability of NLP models to a cohort of patients prescribed with opioids, and explored customization strategies to improve performance. We applied the best NLP model to extract 19 categories of SDoH from the breast (n=7,971), lung (n=11,804), and colorectal cancer (n=6,240) cohorts. Results and Conclusion: We developed a corpus of 629 cancer patients notes with annotations of 13,193 SDoH concepts/attributes from 19 categories of SDoH. The Bidirectional Encoder Representations from Transformers (BERT) model achieved the best strict/lenient F1 scores of 0.9216 and 0.9441 for SDoH concept extraction, 0.9617 and 0.9626 for linking attributes to SDoH concepts. Fine-tuning the NLP models using new annotations from opioid use patients improved the strict/lenient F1 scores from 0.8172/0.8502 to 0.8312/0.8679. The extraction rates among 19 categories of SDoH varied greatly, where 10 SDoH could be extracted from >70% of cancer patients, but 9 SDoH had a low extraction rate (<70% of cancer patients). The SODA package with pre-trained transformer models is publicly available at https://github.com/uf-hobiinformatics-lab/SDoH_SODA.
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We aim at improving reasoning on inconsistent and uncertain data. We focus on knowledge-graph data, extended with time intervals to specify their validity, as regularly found in historical sciences. We propose principles on semantics for efficient Maximum A-Posteriori inference on the new Temporal Markov Logic Networks (TMLN) which extend the Markov Logic Networks (MLN) by uncertain temporal facts and rules. We examine total and partial temporal (in)consistency relations between sets of temporal formulae. Then we propose a new Temporal Parametric Semantics, which may combine several sub-functions, allowing to use different assessment strategies. Finally, we expose the constraints that semantics must respect to satisfy our principles.
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Practical operations of coordinated fleets of mobile robots in different environments reveal benefits of maintaining small distances between robots as they move at higher speeds. This is counter-intuitive in that as speed increases, increased distances would give robots a larger time to respond to sudden motion variations in surrounding robots. However, there is a desire to have lower inter-robot distances in examples like autonomous trucks on highways to optimize energy by vehicle drafting or smaller robots in cluttered environments to maintain communication, etc. This work introduces a model based control framework that directly takes non-linear system dynamics into account. Each robot is able to follow closer at high speeds because it makes predictions on the state information from its adjacent robots and biases it's response by anticipating adjacent robots' motion. In contrast to existing controllers, our non-linear model based predictive decentralized controller is able to achieve lower inter-robot distances at higher speeds. We demonstrate the success of our approach through simulated and hardware results on mobile ground robots.
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从废物电气和电子设备(WEEE)中有效拆卸和回收材料是将全球供应链从碳密集型,采矿材料转移到可回收和可再生的材料的关键步骤。常规的回收过程依赖于切碎和分类废物流,但是对于由许多不同材料组成的Weee,我们探索了针对许多物体的靶向拆卸,以改善材料恢复。许多WEEE对象都共享许多关键特征,因此看起来非常相似,但是它们的材料组成和内部组件布局可能会有所不同,因此,对于随后的拆卸步骤,为准确的材料分离和恢复而具有准确的分类器至关重要。这项工作介绍了RGB-X(一种多模式图像分类方法),该方法利用了来自外部RGB图像的关键特征,并从X射线图像中生成的图像来准确地对电子对象进行分类。更具体地说,这项工作开发了迭代类激活映射(ICAM),这是一种新型的网络体系结构,明确地侧重于用于准确的电子对象分类所需的多模式特征映射中的细节。为了培训分类器,由于费用和需要专家指导,电子对象缺乏大型且注释良好的X射线数据集。为了克服这个问题,我们提出了一种新的方法,可以使用应用于X射线域的域随机化创建合成数据集。合并的RGB-X方法使我们在10代现代智能手机上的准确度为98.6%,其单独的精度为89.1%(RGB)和97.9%(X射线)。我们提供实验结果3来证实我们的结果。
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模块化机器人可以在每天重新排列到新设计中,通过为每项新任务形成定制机器人来处理各种各样的任务。但是,重新配置的机制是不够的:每个设计还需要自己独特的控制策略。人们可以从头开始为每个新设计制作一个政策,但这种方法不可扩展,特别是给出了甚至一小组模块可以生成的大量设计。相反,我们创建了一个模块化策略框架,策略结构在硬件排列上有调节,并仅使用一个培训过程来创建控制各种设计的策略。我们的方法利用了模块化机器人的运动学可以表示为设计图,其中节点作为模块和边缘作为它们之间的连接。给定机器人,它的设计图用于创建具有相同结构的策略图,其中每个节点包含一个深神经网络,以及通过共享参数的相同类型共享知识的模块(例如,Hexapod上的所有腿都相同网络参数)。我们开发了一种基于模型的强化学习算法,交织模型学习和轨迹优化,以培训策略。我们展示了模块化政策推广到培训期间没有看到的大量设计,没有任何额外的学习。最后,我们展示了与模拟和真实机器人一起控制各种设计的政策。
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